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Glucose can diffuse directly into the mitochondria, so the oxidation of glucose is limited only by the biochemical reactions inside the mitochondria

The influence of oxidative stress on thyroid diseases

10.1038/nrm1261 [DOI] [PubMed] [Google Scholar] Birchmeier C., Gherardi E

Gentle, stable derivatives like 3-O-ethyl ascorbic acid provide all the antioxidant and brightening benefits with a much lower risk of irritation compared to pure L-ascorbic acid

Therefore, the applicant estimates the average dose of medication during an inpatient stay to be 600 mg, given the initial 400 mg dose plus one 200 mg maintenance dose prior to discharge from the hospital